Some of the most common side effects of semaglutide include nausea, vomiting, diarrhea, constipation, abdominal pain, headache, fatigue, indigestion, dizziness, hypoglycemia (low blood sugar) in patients with type 2 diabetes, and flatulence (gas buildup). Incidence of nausea can increase at higher doses so slow
titration (dose increasing) can help decrease the possibility of side effects.
Nausea is the most common side effect in users of semaglutide happening in up to 20% of patients especially at higher doses. A mild amount of nausea is normal when starting semaglutide or when slowly increasing the dose of semaglutide.
Nausea can occur more frequently if an individual continues to eat after feeling full. It is recommended to eat smaller meals to help avoid this. Some recommendations to help decrease nausea are over the counter medication such as Dramamine or Bonnie. Additionally eating ginger chews or something sour can help as well.